Long commutes and scarcity of providers make it hard for patients who need counseling or psychiatric care.
In the early 1990s, people in this economically depressed region lagged only slightly behind other parts of the country. Today, rates of infant mortality in Appalachia are significantly higher than elsewhere, and the difference in life expectancy has grown noticeably.
Report by CDC researchers finds a steady fall in opioid use in recent years, but the rates are still three times higher than in 1999.
A study finds that nearly 19 percent of people with mental illnesses use prescription drugs, while only 5 percent of other people do.